TheChlamydiaprotease CPAF: Caution, Precautions And Function

The Chlamydia protease CPAF: caution, precautions and function.

Recent biochemical and genetic studies have called into question many of the functions proposed for the chlamydial protease CPAF (Zhong et al., 2001). In 2012, we demonstrated that the proteolysis of multiple reported substrates was occurring during the preparation of lysates from Chlamydia-infected cells rather than in intact cells (Chen et al., 2012). The recent report by Snavely et al. of a ...

Injectable Corticosteroids: Take Precautions and Use Caution.

Corticosteroids are routinely injected into soft tissues, tendon sheaths, bursae, and joints. These anti-inflammatory agents have different potency and solubility, and solubility is inversely correlated with the duration of action. Corticosteroids carry a low risk of complications but commonly cause systemic and local adverse effects. The use of intra-articular corticosteroid injections in the ...

compactifications and function spaces on weighted semigruops

chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...

Predicting the impact of contact precautions on methicillin-resistant Staphylococcus aureus outcomes: caution up ahead.

Is the hoopla over CPAF justified?

It may be worth asking whether all the hoopla over CPAF is justified. Our view is: yes, it is. As in any active scientific area, not every proposal regarding CPAF function has held up. The recent developments are very encouraging: we now have a much better idea of what CPAF can do, but also what it does not do. Our current knowledge can be summarized as follows: Chlamydiae produce a potent prot...